Luteolin, mostly in the form of glycoside exists in a variety of plants, these plants with whole leaf green orchid, pepper, wild chrysanthemum, honeysuckle, Perilla content is high. It has antitussive and expectorant effects. According to the latest research, respiratory symptoms cough, expectoration, wheezing, are related to chronic airway inflammation. Such as bronchial asthma, chronic obstructive pulmonary disease, chronic pharyngitis, allergic rhinitis and other causes of cough, expectoration, wheezing, are considered to be related to local inflammatory infiltration, the presence of inflammation, the airway immune response confusion, patients often appear increased airway reactivity. Treatment should begin by eliminating chronic inflammatory infiltration in the airway. Glucocorticoids are commonly used to eliminate airway inflammation. However, glucocorticoid has many side effects and should not be used for a long time. Studies have shown that luteolin inhibits macrophage phosphorylation, inhibits the activity of transcription factor NF-kB, and inhibits lipopolysaccharide (LPS) -induced macrophage production of cytokines IL-6 and TNF- A. In addition, studies have also shown that luteolin inhibits uric acid production and promotes uric acid excretion. [3-4] The latter two cytokines play a very important role in the mechanism of inflammation and are sensitive indicators reflecting the degree of inflammation. Luteolin also increased IFN-γ, decreased specific Ig-E, and decreased eosinophilic infiltration. In addition, in addition to anti-inflammatory and anti-allergic effects, luteolin also has anti-PDE, anti-SARS, HIV properties, the reason is to inhibit the activity of S protein before SARS virus, thus preventing it from entering host cells. For the treatment of COPD, bronchial asthma, and chronic pharyngitis, allergic rhinitis caused by chronic cough.
Post time: Jan-12-2021